LONDON: Renowned boxer Amir Khan responded by splashing water towards Lo Greco after he made personal comments about Faryal Makhdoom.
Lo Greco unnecessarily pointed to Khan's family issues and made irritating personal comments that led Amir Khan throwing a glass of water in his future opponent's face.
After security had calmed the clash on stage, promoter Eddie Hearn asked Lo Greco to apologise, while Khan later said his rival's behaviour would serve as motivation to "give this guy a beating". The pair will meet in Liverpool on 21 April.
Khan, flanked by his father Shah at the media event, refused to apologise to Lo Greco for throwing water but said sorry to those in attendance.
Lo Greco said: "After the Canelo loss you went on a losing streak - family, wife, and then you go out and tweet to the heavyweight champion of the world. What is wrong with you, mate?"
Amir Khan, who has won 31 of his 35 professional bouts, has signed a three-fight deal with Matchroom after ending a long-running feud with Hearn.
"I will train like it's a world-title fight," said Khan. "Greco says maybe I'm past my best. I'm 31 and at the peak of my career. For me, boxing is the way forward. Boxing put me here and I am going to finish on a high.